粒细胞集落刺激因子对靶细胞的作用机制及其常用制剂的临床药理研究和应用进展(4)
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[ 4 ] KAST RE，HILL QA，WION D，et al. Glioblastoma-synthesized G-CSF and GM-CSF contribute to growth and immunosuppression：potential therapeutic benefit from dapsone，fenofibrate，and ribavirin[J]. Tumour Biol，2017，39(5)：1-10.
, http://www.100md.com
[ 5 ] TOUW IP，PALANDE K，BEEKMAN R. Granulocyte colony-stimulating factor receptor signaling：implications for G-CSF responses and leukemic progression in severe congenital neutropenia[J]. Hematol Oncol Clin North Am，2013，27(1)：61-73.
[ 6 ] LIONGUE C，WARD AC. Granulocyte colony-stimulating factor receptor mutations in myeloid malignancy[J]. Front Oncol，2014.DOI：10.3389/fonc.2014.00093.
[ 7 ] MEHTA HM，MALANDRA M，COREY SJ. G-CSF and GM-CSF in neutropenia[J]. J Immunol，2015，195(4)：1341-1349.
, http://www.100md.com
[ 8 ] ALIPER AM，FRIEDEN-KOROVKINA VP，BUZDIN A，et al. A role for G-CSF and GM-CSF in nonmyeloid cancers[J]. Cancer Med，2014，3(4)：737-746.
[ 9 ] DWIVEDI P，GREIS KD. Granulocyte Colony Stimulating Factor Receptor (G-CSFR) signaling in severe congenital neutropenia，chronic neutrophilic leukemia and related malignancies[J]. Exp Hematol，2017.DOI：10.1016/j.exphem.2016.10.008.
[10] CHATZIMPALOGLOU A，KOLOSOV M，ECKOLS TK，et al. Synthetic and biological studies of phaeosphaerides[J]. J Org Chem，2014，79(9)：4043-4054.
, http://www.100md.com
[11] WARD AC，HERMANS MH，SMITH L，et al. Tyrosine- dependent and -independent mechanisms of STAT3 activation by the human granulocyte colony-stimulating factor (G-CSF) receptor are differentially utilized depending on G-CSF concentration[J]. Blood，1999，93(1)：113-124.
[12] YU H，LIU Y，MCfarland BC，et al. SOCS3 deficiency in myeloid cells promotes tumor development：involvement of STAT3 activation and myeloid-derived suppressor cells[J]. Cancer Immunol Res，2015，3(7)：727-740.
, http://www.100md.com
[13] DE LA LUZ SIERRA M，SAKAKIBARA S，GASPERINI P，et al. The transcription factor Gfi1 regulates G-CSF signaling and neutrophil development through the Ras activator RasGRP1[J]. Blood，2010，115(19)：3970-3979.
[14] NAKAOKA Y，KOMURO I. Gab docking proteins in cardiovascular disease，cancer，and inflammation[J]. Int J Inflam，2013.DOI：10.1155/2013/141068., 百拇医药(李菲 王斌 舒斯云 马林)
[ 3 ] CUI YH，SUH Y，LEE HJ，et al. Radiation promotes invasiveness of non-small-cell lung cancer cells through granulocyte-colony-stimulating factor[J]. Oncogene，2015，34(42)：5372-5382.
[ 4 ] KAST RE，HILL QA，WION D，et al. Glioblastoma-synthesized G-CSF and GM-CSF contribute to growth and immunosuppression：potential therapeutic benefit from dapsone，fenofibrate，and ribavirin[J]. Tumour Biol，2017，39(5)：1-10.
, http://www.100md.com
[ 5 ] TOUW IP，PALANDE K，BEEKMAN R. Granulocyte colony-stimulating factor receptor signaling：implications for G-CSF responses and leukemic progression in severe congenital neutropenia[J]. Hematol Oncol Clin North Am，2013，27(1)：61-73.
[ 6 ] LIONGUE C，WARD AC. Granulocyte colony-stimulating factor receptor mutations in myeloid malignancy[J]. Front Oncol，2014.DOI：10.3389/fonc.2014.00093.
[ 7 ] MEHTA HM，MALANDRA M，COREY SJ. G-CSF and GM-CSF in neutropenia[J]. J Immunol，2015，195(4)：1341-1349.
, http://www.100md.com
[ 8 ] ALIPER AM，FRIEDEN-KOROVKINA VP，BUZDIN A，et al. A role for G-CSF and GM-CSF in nonmyeloid cancers[J]. Cancer Med，2014，3(4)：737-746.
[ 9 ] DWIVEDI P，GREIS KD. Granulocyte Colony Stimulating Factor Receptor (G-CSFR) signaling in severe congenital neutropenia，chronic neutrophilic leukemia and related malignancies[J]. Exp Hematol，2017.DOI：10.1016/j.exphem.2016.10.008.
[10] CHATZIMPALOGLOU A，KOLOSOV M，ECKOLS TK，et al. Synthetic and biological studies of phaeosphaerides[J]. J Org Chem，2014，79(9)：4043-4054.
, http://www.100md.com
[11] WARD AC，HERMANS MH，SMITH L，et al. Tyrosine- dependent and -independent mechanisms of STAT3 activation by the human granulocyte colony-stimulating factor (G-CSF) receptor are differentially utilized depending on G-CSF concentration[J]. Blood，1999，93(1)：113-124.
[12] YU H，LIU Y，MCfarland BC，et al. SOCS3 deficiency in myeloid cells promotes tumor development：involvement of STAT3 activation and myeloid-derived suppressor cells[J]. Cancer Immunol Res，2015，3(7)：727-740.
, http://www.100md.com
[13] DE LA LUZ SIERRA M，SAKAKIBARA S，GASPERINI P，et al. The transcription factor Gfi1 regulates G-CSF signaling and neutrophil development through the Ras activator RasGRP1[J]. Blood，2010，115(19)：3970-3979.
[14] NAKAOKA Y，KOMURO I. Gab docking proteins in cardiovascular disease，cancer，and inflammation[J]. Int J Inflam，2013.DOI：10.1155/2013/141068., 百拇医药(李菲 王斌 舒斯云 马林)